wikitox:kinetics_problem
Kinetics Problems
PROBLEM 1
Consider the effect on free drug concentration of an increase in protein binding of 1% for 3 drugs whose protein bindings are 95%, 80% and 50%.
Would there be any difference if the change in protein binding occured in minutes versus over 2 weeks?
PROBLEM 2
A 50 kilogram woman ingests 5000 mg of controlled release theophylline. The average Vd for theophylline is 0.5 litres/kg.
- What is the likely peak concentration if it is fully absorbed?
- Theophylline is metabolised by P450 enzymes. What is the likely impact of this dose on theophylline’s metabolism and elimination?
- The half-life was calculated using 2 levels 6 hours apart. The half-life appeared to be 10 hours. What factors may contribute to this result. What are some of the potential sources of error in such a calculation?
wikitox/kinetics_problem.txt · Last modified: 2018/09/01 09:01 by 127.0.0.1