Atropine-like reactions may occur with several plants, some of which are used by drug abusers. The major clinical manifestations are nausea, dry skin & mouth, tachycardia, mydriasis, delirium, hallucinations, convulsions and urinary retention (the anticholinergic toxidrome).

The most common plants are:

• Datura and Brugmansia species (aka Jimsonweed, Thornapple, Stinkweed, Jamestownweed, Devil's apple, Angel's trumpet, Loco seed, Melpitte, Green dragon, Stramonium and Apple of Peru)
• Atropa belladonna (Deadly nightshade)
• Duboisia myoporoides (Corkwood)

Specific treatment consists of sedatives (diazepam), anticholinesterase inhibitors (physostigmine, tacrine), and avoidance of anticholinergic drugs (e.g. neuroleptics).

• Marijuana
• Mushrooms (Psilocybe , Amanita)
• Peyote
• Morning Glory (Convolvulaceae) (LSD like)
• Claviceps purpurea (ergot)
• Nutmeg