Seizures

The following drugs directly cause seizures (though so does hypotension).

• Propranolol and oxprenolol
• Tricyclic antidepressants
• Antipsychotic drugs (particularly chlorpromazine and thioridazine)
• Anticonvulsants (particularly barbiturates, carbamazepine and phenytoin)
• Dextropropoxyphene
• Antimalarial drugs (chloroquine, quinine)
• Antiarrhythmic drugs
• Orphenadrine
• Lithium

Seizures are commonly seen in severe poisonings with all the following drugs:

• Tricyclic antidepressants
• Anticonvulsants (particularly carbamazepine and phenytoin)
• Antimalarial drugs (chloroquine, quinine)
• Beta blockers (particularly propranolol)
• Antiarrhythmic drugs
• Orphenadrine
• Lithium
• Chloral hydrate
• Adrenergic drugs (theophylline, cocaine and amphetamines)
• Drugs that lead to tissue hypoxia, acidosis or hypoglycaemia ( CO, organochlorines, hypoglycaemic drugs, insulin, isoniazid, salicylates etc.)