Core Principles Section 1: Pharmacokinetics and Pharmacodynamics

Work your way through each section; ideally you should read the associated references.

WikiTox Pharmacokinetics and Pharmacodynamics

1. Evans WE, McLeod HL. Pharmacogenomics Drug disposition, drug targets, and side effects. N Engl J Med 2003;348(6):538-550. (fulltext)
2. Martin J, Fay M. Cytochrome P450 drug interactions: are they clinically relevant? Australian Prescriber 2001;24(1):10-12. (fulltext)
3. Roberts D Buckley N Pharmacokinetic considerations in clinical toxicology: clinical applications. Clin Pharmacokinet. 2007;46(11):897-939

• Kinetics Problem

• WikiTox Clinical Toxicology
  • Assessment of patients
  • Decontamination
  • Gastrointestinal Decontamination
  • Enhanced Elimination

1. American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicology. Position statement: Ipecac syrup. Clinical Toxicology . (fulltext)
2. American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicology. Position statement: Gastric lavage. Clinical Toxicology .(fulltext)
3. American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicology. Position statement: Single-dose activated charcoal. Clinical Toxicology .(fulltext) also Multiple dose charcoal
4. American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicology. Position statement: Whole bowel irrigation. Clinical Toxicology (fulltext)
5. For a commentary on all of these papers see The revised position papers on gastric decontamination Buckley & Eddleston
6. Isbister GK, Dawson AH, Whyte IM. Feasibility of prehospital treatment with activated charcoal: Who could we treat, who should we treat? Emerg Med J 2003;20:375-378. (fulltext)
7. Eddleston M, Juszczak E, Buckley NA, Senarathna L, Mohamed F, Dissanayake W,Hittarage A, Azher S, Jeganathan K, Jayamanne S, Sheriff MR, Warrell DA; Ox-Col Poisoning Study collaborators. Multiple-dose activated charcoal in acute self-poisoning: a randomised controlled trial. Lancet. 2008 Feb 16;371(9612):579-87. (fulltext)
8. de Silva HA, Fonseka MM, Pathmeswaran A, Alahakone DG, Ratnatilake GA, Gunatilake SB, Ranasinha CD, Lalloo DG, Aronson JK, de Silva HJ. Multiple-dose activated charcoal for treatment of yellow oleander poisoning: a single-blind, randomised, placebo-controlled trial. Lancet. 2003 Jun 7;361(9373):1935-8 (fulltext)

• Decontamination Problem