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Link to 2.1.11.4.1 Anticholinergics Teaching Resources
Link to Problems for Discussion
Anticholinergic Toxidrome
Introduction
Anticholinergic toxicity, to varying degrees, is seen relatively frequently in toxicology patients. The main clinical challenge is the safe management of the delirium which occurs due to ventra anticholinergic effects.
The mainstay of treatment is supportive care, whilst time is allowed for the toxicity to resolve; however, patients frequently require sedation and antidotal therapy with physostigmine/rivastigmine for both their own and staff safety.
Anticholinergic drugs
Ther are many drugs and natural substances that have anticholinergic effects.
Pure anticholinergic agents include:
- Atropine
- Benzatropine
- Hyoscine
Drugs with anticholinergic effects include:
- Antihistamines
- Tri-cyclic antidepressants
- Antipsychotics e.g. quetiapine, olanzapine
Plants with anticholinergic effects include:
- Brugmansia species
- Atropa belladonnna
- Datura stamonium
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