1.1.1 Pharmacokinetics and Toxicokinetics

• 1.1.1.1 Bioavailability and Absorption
• 1.1.1.2 Distribution
• 1.1.1.3 Metabolism
• 1.1.1.4 Elimination
• 1.1.1.5 Clearance
• 1.1.1.6 Models (eg. compartmental, physiologic)

1.1.2 Pharmacodynamics and Toxicodynamics

• 1.1.2.1 Dose-Concentration Relationship to Effect
• 1.1.2.2 Structure-Activity Relationship
• 1.1.2.3 Receptor Agonism/Antagonism
• 1.1.2.4 Receptor Regulation

1.1.3 Adverse Effects

• 1.1.3.1 Mechanistic (predictable)
• 1.1.3.2 Idiosyncratic

1.1.4 Interactions

• 1.1.4.1 Xenobiotic-Environment
• 1.1.4.2 Xenobiotic-Food
• 1.1.4.3 Xenobiotic-Xenobiotic (eg, drug-drug)

1.1.5 Proteomics

1.1.6 Tolerance and Withdrawal

• 1.1.6.1 Behavioral Tolerance
• 1.1.6.2 Biologic Tolerance

1.1.7 Immunologic Response (eg, antibodies, cytokines)

1.1.8 Pharmacogenomics and Toxicogenomics (eg, xenobiotic response, gene expression profiling)