Serotonergic Drug Interactions
Any combination of the following drugs may lead to increased serotonergic effects (also see serotonin biosynthesis and metabolism).
| L-Tryptophan, S-adenyl-L-methionine, 5-hydroxytryptophan,dopamine | Serotonin precursors |
| SSRIs (citalopram, fluoxetine, fluvoxamine, paroxetine, sertraline), venlafaxine, chlorpheniramine | Inhibit serotonin reuptake |
| TCAs (clomipramine, imipramine) | Inhibit serotonin reuptake |
| Tramadol | Inhibit serotonin reuptake |
| Fenfluramine, p-chloramphetamine, bromocriptine, dihydroergotamine, gepirone, eltoprazin, quipazine | Serotonin agonists |
| MAO Inhibitors (clorgyline, isocarboxazid, nialamide, pargyline, phenelzine, tranylcypromine) | Inhibit metabolism of serotonin |
| RIMAs (brofaramine, befloxatone, toloxatone, moclobemide) | Inhibit metabolism of serotonin |
| Lithium | Unknown |
| Opioids (dextromethorphan, pentazocine, pethidine) | Inhibit serotonin reuptake |
| LSD | Partial serotonin agonist |
| Cocaine | Inhibit serotonin reuptake |
| Ecstasy (MDMA) | Increases serotonin release and inhibits reuptake |