The following drugs directly cause coma. However, coingestion of sedative drugs is common.

• Propranolol and oxprenolol
• Tricyclic antidepressants
• Antipsychotic drugs (particularly chlorpromazine and thioridazine)
• Anticonvulsants (particularly barbiturates, carbamazepine and phenytoin)
• Dextropropoxyphene
• Antimalarial drugs (chloroquine, quinine)
• Antiarrhythmic drugs
• Orphenadrine
• Lithium