3.3 Pharmacological Basis of Antidote Use

Talk by Vincent Danel EAPCCT Seville on prehospital antidote:
Antidotes Danel Seville.ppt [1.8 MB]

• 3.3.1 Antagonize Effects of Poison
  • 3.3.1.1 Enzyme Inhibitors (eg, physostigmine)
  • 3.3.1.2 Enzyme Reactivators (eg, pralidoxime)
  • 3.3.1.3 Physiological Antagonists (eg, calcium, glucagon)
  • 3.3.1.4 Receptor Antagonists (eg, atropine, flumazenil, naloxone)
  • 3.3.1.5 Reducing Agent (eg, methylene blue, N-acetylcysteine)

• 3.3.2 Dispositional Agents
  • 3.3.2.1 Alcohol Dehydrogenase Antagonists
  • 3.3.2.2 Antivenoms/Antibodies
  • 3.3.2.3 Chelators
  • 3.3.2.4 Cyanide Antidotes
  • 3.3.2.5 Enzyme/Cofactor Replacement (eg, folinic acid, pyridoxine)
  • 3.3.2.6 Oxygen/Hyperbaric Oxygen

• 3.3.3 Other Antidotes