Bicarbonate is the primary antidote for TCA poisoning. As these are, by far, the most common cause of cardiac arrest in out of hospital poisonings - patients with drug overdose presenting in cardiac arrest or arresting shortly after arrival should receive a bolus of 1 ampoule of NaHCO₃.

The patient should then be hyperventilated.

Indication 1 (e.g. Symptom/sign X in [link to toxicity].)

• Adult: 💊 DrugName Dose Route, Frequency.
• Child: 💊👶 DrugName Dose Route, Frequency.
• Other notes if applicable.

Indication 2 (e.g. Symptom/sign X in [link to toxicity].)

• Adult:
  • 💊 DrugName Dose Route, Frequency.
  • 💊 DrugName Dose Route, Frequency.
• Child:
  • 💊👶 DrugName Dose Route, Frequency.
  • 💊👶 DrugName Dose Route, Frequency.
• Other notes if applicable.

Pregnancy rating:

Lactation:

Renal impairment:

Hepatic impairment:

• Description of important/serious adverse effects, e.g.
• Serotonin syndrome:
• Systems e.g.
• GI:
• Resp:
• MSK: local phlebitis
• Frequency e.g.
• Common:

Mechanism of action:

Absorption:

• Oral bioavailability:
• GI tract absorption:
• First pass metabolism:

Distribution:

• Vd:
• Lipid solubility:
  • Crosses/Does not cross BBB
  • Crosses/Does not cross placenta
  • Excreted/Not excreted in breast milk
• Protein binding:
• Tmax:

Metabolism:

Excretion:

• Elimination t½:
• Hepatic clearance:
• Renal clearance:

Formulation:

Useful general references: