**[[:wikitox:1.1.1_pharmacokinetics_and_toxicokinetics|1.1.1 Pharmacokinetics and Toxicokinetics]]**
  * [[:wikitox:1.1.1.1_bioavailability_and_absorption|1.1.1.1 Bioavailability and Absorption]]
  * [[:wikitox:1.1.1.2_distribution|1.1.1.2 Distribution]]
  * [[:wikitox:1.1.1.3_metabolism|1.1.1.3 Metabolism]]
  * [[:wikitox:1.1.1.4_elimination|1.1.1.4 Elimination]]
  * [[:wikitox:1.1.1.5_clearance|1.1.1.5 Clearance]]
  * 1.1.1.6 Models (eg. compartmental, physiologic)

**1.1.2 Pharmacodynamics and Toxicodynamics**

  * [[:wikitox:1.1.2.1_dose_and_concentration_relationship_to_effect|1.1.2.1 Dose-Concentration Relationship to Effect]]
  * 1.1.2.2 Structure-Activity Relationship
  * [[:wikitox:1.1.2.3_receptor_agonism_and_antagonism|1.1.2.3 Receptor Agonism/Antagonism]]
  * 1.1.2.4 Receptor Regulation

**[[:wikitox:1.1.3_adverse_effects|1.1.3 Adverse Effects]]**
  * 1.1.3.1 Mechanistic (predictable)
  * 1.1.3.2 Idiosyncratic

**1.1.4 Interactions**

  * 1.1.4.1 Xenobiotic-Environment
  * 1.1.4.2 Xenobiotic-Food
  * 1.1.4.3 Xenobiotic-Xenobiotic (eg, drug-drug)

**1.1.5 Proteomics**

**1.1.6 Tolerance and Withdrawal**

  * 1.1.6.1 Behavioral Tolerance
  * 1.1.6.2 Biologic Tolerance

**1.1.7 Immunologic Response (eg, antibodies, cytokines)**

**1.1.8 Pharmacogenomics and Toxicogenomics (eg, xenobiotic response, gene expression profiling)**