Link to [[:wikitox:core_information|Core Information]]\\ Link to [[:wikitox:core_principles_section_1_pharmacokinetics_dynamics|Core Principles Overview]]\\ Link to [[:wikitox:teaching_resources|Teaching Resources]] ---- ====== 1.1.1 Pharmacokinetics and Toxicokinetics Contribution Teaching Resources ====== ===== SUGGESTED READING ===== - Evans WE, McLeod HL. Pharmacogenomics Drug disposition, drug targets, and side effects. N Engl J Med 2003;348(6):538-550. [[http://content.nejm.org/cgi/content/full/348/6/538|(fulltext)]] - Martin J, Fay M. Cytochrome P450 drug interactions: are they clinically relevant? Australian Prescriber 2001;24(1):10-12. [[http://www.australianprescriber.com/upload/pdf/articles/425.pdf|(fulltext)]] - Albertson TE, Dawson A, de Latorre F, Hoffman RS, Hollander JE, Jaeger A, et al. TOX-ACLS: toxicologic-orientated advanced cardiac life support. [[http://www.ncbi.nlm.nih.gov/pubmed/11290973?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum|Ann Emerg Med Apr 2001;37:S78-S90]]. - Buckley NA, Whyte IM, Dawson AH. Diagnostic data in clinical toxicology Should we use a Bayesian approach? [[http://www.ncbi.nlm.nih.gov/pubmed/12144194?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum|Clinical Toxicology 2002;40(3):213-222]]. - American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicology. Position statement: Ipecac syrup. Clinical Toxicology . [[http://www.eapcct.org/publicfile.php?folder=congress&file=PS_IpecacSyrup.pdf|(fulltext)]] - American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicology. Position statement: Gastric lavage. Clinical Toxicology .[[http://www.eapcct.org/publicfile.php?folder=congress&file=PS_GastricLavage.pdf|(fulltext)]] - American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicology. Position statement: Single-dose activated charcoal. Clinical Toxicology .[[http://www.eapcct.org/publicfile.php?folder=congress&file=PS_SingleDoseActivatedCharcoal.pdf|(fulltext)]] also [[http://www.eapcct.org/publicfile.php?folder=congress&file=PS_MultipleDoseActivatedCharcoal.pdf|Multiple dose charcoal]] - American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicology. Position statement: Whole bowel irrigation. Clinical Toxicology [[http://www.eapcct.org/publicfile.php?folder=congress&file=PS_WholeBowelIrrigation.pdf|(fulltext)]] - For a commentary on all of these papers see [[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1351142/|The revised position papers on gastric decontamination Buckley & Eddleston]] - Isbister GK, Dawson AH, Whyte IM. Feasibility of prehospital treatment with activated charcoal: Who could we treat, who should we treat? Emerg Med J 2003;20:375-378. [[http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=12835364|(fulltext)]] - Eddleston M, Juszczak E, Buckley NA, Senarathna L, Mohamed F, Dissanayake W,Hittarage A, Azher S, Jeganathan K, Jayamanne S, Sheriff MR, Warrell DA; Ox-Col Poisoning Study collaborators. Multiple-dose activated charcoal in acute self-poisoning: a randomised controlled trial. [[http://www.ncbi.nlm.nih.gov/pubmed/18280328?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum|Lancet. 2008 Feb 16;371(9612):579-87.]] (fulltext) - de Silva HA, Fonseka MM, Pathmeswaran A, Alahakone DG, Ratnatilake GA, Gunatilake SB, Ranasinha CD, Lalloo DG, Aronson JK, de Silva HJ. Multiple-dose activated charcoal for treatment of yellow oleander poisoning: a single-blind, randomised, placebo-controlled trial. [[http://www.ncbi.nlm.nih.gov/pubmed/12801736?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_Discovery_RA&linkpos=2&log$=relatedarticles&logdbfrom=pubmed|Lancet. 2003 Jun 7;361(9373):1935-8]] ([[http://www.thelancet.com/journals/lancet/article/PIIS0140673603135817/fulltext|fulltext]]) - Greene S. Harris C. Singer J. Gastrointestinal decontamination of the poisoned patient. [Review] [78 refs] [Journal Article. Review] [[http://www.ncbi.nlm.nih.gov/pubmed/18347499?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum|Pediatric Emergency Care. 24(3):176-86; quiz 187-9, 2008 Mar.]] - [[http://www.ncbi.nlm.nih.gov/pubmed/17922558?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum|Roberts D Buckley N Pharmacokinetic considerations in clinical toxicology: clinical applications. Clin Pharmacokinet. 2007;46(11):897-939]] ===== TEACHING FILES ===== |**File Name** |**File Type** |**Audience** |**Previous Use** |**Year Created** |**Country of Origin** |**Associated Files** |**Submitted by** | |{{:wikitox:pharmacokinetics.ppt|Pharmacokinetics.ppt}} [56 KB]|PPT|Undergraduates| |1997| | |David Hendry| |{{:wikitox:drug_handling_in_kidney_and_liver_disease_2005.ppt|Drug Handling in kidney and liver disease 2005.ppt}} [234 KB]|PPT|Undergraduates| |2005| | |David Hendry| |{{:wikitox:toxicokinetics_questions_for_acmt_course_2004.doc|Toxicokinetics Questions for ACMT course 2004.doc}} [35 KB]|Word Doc|Toxicology Fellows| |2004|USA| |Kent Olson| |{{:wikitox:toxicokinetics_2004.ppt|Toxicokinetics 2004.ppt}} [1.6 MB]|PPT|Toxicology Fellows| |2004|USA| |Kent Olson| |{{:wikitox:elderly_danel.ppt|Elderly Danel.ppt}} [346 KB]|PPT|EAPCCT| |2006|France| |Vincent Danel| | | | | | | | | | \\