====== 3.3.1.1.1 Physostigmine ======

A rapid response to physostigmine will occur in patients with pure [[:wikitox:2.1.11.4.1_anticholinergics|anticholinergic]] CNS effects. Less response will be seen with [[:wikitox:2.1.11.9.2.1_tricyclic_antidepressants|TCA, ]] [[:wikitox:2.1.11.9.3_antipsychotics|neuroleptic]] and [[:wikitox:3.4.2.3_carbamazepine|carbamazepine]] ingestions.

This test is potentially hazardous in TCA poisoning where it may precipitate seizures and cardiac arrest.

**PHYSOSTIGMINE SHOULD NOT BE USED IF THE ECG IS ABNORMAL!!**

|**File number** |**File Type** |**Audience** |**Previous** |**Year created** |**Country of Origin** |**Associated files** |**Submitted by** |
|{{:wikitox:physostigmine_hoffman.ppt|Physostigmine.ppt}}  [887 KB]|PPT|Postgrad|EAPCCT Keynote|2003|USA|None|Bob Hoffman|
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