This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong. ====== Module 2 - Antidiabetic drugs, Analgesics and NSAIDs, Opioids, Methotrexate and Colchicine ====== ===== OBJECTIVES ===== At the end of this module, students should be able to:\\ · Understand the mechanisms underlying the toxicity of these agents\\ · Undertake a risk assessment of poisoning\\ · Be aware of agents that have a delayed onset or protracted time course of poisoning and how patients should be monitored\\ · Understand the role and limitations of specific antidotes, where available\\ · Develop an approach for the treatment of these drugs, as single ingestants or co-ingestants. ===== BIGUANIDES, SULPHONYLUREAS AND INSULIN ===== ==== Objectives ==== * Understand the mechanism of toxicity and clinical effects including time course of hypoglycaemic agents * Understand the role of antidotes in hypoglycaemic poisoning * Understand some of the complexities in a medicolegal toxicology case ==== Reading ==== [[:biguanide_toxicity|Biguanides]], [[:wikitox:2.1.7.1.2_sulphonylureas|Sulphonylureas]] and [[:wikitox:2.1.7.1.1_insulin|Insulin]] See: **[[:wikitox:problems_for_discussion_2_biguanides_sulphonylureas_and_insulin|Problems for Discussion]]** ===== ANALGESICS AND ANTI-INFLAMMATORY NSAID POISONING ===== ==== Paracetamol ==== **Objectives** * To be able to do a risk assessment of a paracetamol poisoning * Consider variables which may affect the risk assessment * Understand the limitations of the nomogram * Understand treatment of paracetamol poisoning * Discuss the effective methods of gastric decontamination in paracetamol overdose * Discuss the efficacy of available antidotes based on strength of evidence * Discuss the problems of management when working in resource poor settings * Compare the differences in prognosis and management in acute deliberate and accidental paracetamol overdose. **Reading** [[:wikitox:2.1.1.1_acetaminophen|WikiTox Acetaminophen]] See: **[[:wikitox:problems_for_discussion_2_analgesics_and_anti_inflammatory_nsaid_poisoning|Problems for Discussion]]** ==== Anti-inflammatory NSAID ==== **Objectives** * Understand the mechanism of toxicity of NSAIDs. * Understand the potential complications of NSAID overdose in general and which agents have specific toxicities. **Reading** Analgesics and [[:wikitox:2.1.1.2_nonsteroidal_anti_inflammatory_drugs|Anti-inflammatory NSAID]] Poisoning See: **[[:wikitox:problems_for_discussion_2_analgesics_and_anti_inflammatory_nsaid_poisoning|Problems for Discussion]]** ===== OPIOIDS ===== ==== Reading ==== [[:wikitox:2.1.1.3_opioids|WikiTox Opioids]] See: **[[:wikitox:problems_for_discussion_2_opioids|Problems for Discussion]]** ===== METHOTREXATE ===== ==== Reading ==== [[:wikitox:methotrexate|WikiTox Methotrexate]] See: **[[:wikitox:problems_for_discussion_2_methotrexate|Problems for Discussion]]** ===== COLCHICINE ===== ==== Objectives ==== * Understand the mechanism of toxicity * Be able to make a risk assessment * Understand the issues underlying the provision of antidotes ==== Reading ==== [[:wikitox:2.1.1.5.1_colchicine|Colchicine]] See: **[[:wikitox:problems_for_discussion_2_colchicine|Problems for Discussion]]** CKG Edit