This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong. ====== Problems for Discussion - 2 - Methotrexate ====== ===== Problem 1 ===== A 65-year-old woman with rheumatoid arthritis is prescribed methotrexate 10 mgs weekly. She presents to the emergency department with a history of diarrhoea and a sore mouth.\\ On further history it is apparent that she has mistakenly taken her methotrexate on a daily basis for the past two weeks. - What additional risk factors for methotrexate toxicity may she have? - How would you define her risk of toxicity? CKG Edit