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wikitox:enhanced_elimination [2025/02/17 00:35] – kharriswikitox:enhanced_elimination [2025/02/24 21:25] (current) – kharris
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 ===== Multi-dose Activated Charcoal ===== ===== Multi-dose Activated Charcoal =====
  
-Multi dose activated charcoal (MDAC) enhances elimination through the interruption of enterohepatic recirculation (binding of drugs excreted into the bile before they are reasorbed further along the GI tract) and gastrointestinal dialysis (where lipid soluble, low molecular weight drugs move from gut capillaries back into the lumen down their concentration gradient and bind to charcoal, which in turn maintains the gradient).+Multi dose activated charcoal (MDAC) enhances elimination through the interruption of enterohepatic recirculation (binding of drugs excreted into the bile before they are reabsorbed further along the GI tract) and gastrointestinal dialysis (where lipid soluble, low molecular weight drugs move from gut capillaries back into the lumen down their concentration gradient and bind to charcoal, which in turn maintains the gradient).
  
 MDAC can be considered for a potentially toxic overdose of a drug with a long half-life but small volume of distribution. Complications include constipation, aspiration, and obstruction. MDAC can be considered for a potentially toxic overdose of a drug with a long half-life but small volume of distribution. Complications include constipation, aspiration, and obstruction.