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| wikitox:2.1.1.5.1_colchicine [2025/02/18 00:38] – kharris | wikitox:2.1.1.5.1_colchicine [2025/02/24 21:44] (current) – kharris | ||
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| ==== Supportive ==== | ==== Supportive ==== | ||
| - | Early intervention of airway and breathing are unlikely to be needed but may be required if significant toxicity develops. In large ingestions, where are patient is refusing potential lifesaving decontamination, | + | Early intervention of airway and breathing are unlikely to be needed but may be required if significant toxicity develops. In large ingestions, where a patient is refusing potential lifesaving decontamination, |
| Early hypotension will likely be due to significant fluid losses due to GI toxicity and should be treated with fluid replacement. As toxicity progresses, myocardial depression may develop. A bedside echocardiogram can be helpful in determining if ongoing hypotension is cardiogenic or vasodilatory in nature. If cardiac function is depressed, then adrenaline is first line. If cardiac function is maintained, then target vasoplegia with noradrenaline being first line. | Early hypotension will likely be due to significant fluid losses due to GI toxicity and should be treated with fluid replacement. As toxicity progresses, myocardial depression may develop. A bedside echocardiogram can be helpful in determining if ongoing hypotension is cardiogenic or vasodilatory in nature. If cardiac function is depressed, then adrenaline is first line. If cardiac function is maintained, then target vasoplegia with noradrenaline being first line. | ||
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| ==== Decontamination ==== | ==== Decontamination ==== | ||
| - | Given the severity of toxicity that may develop and the lack of antidote, early decontamination is a vital intervention. The below table gives the doses ingested and the risk factors present that determine whether decontamination | + | Given the severity of toxicity that may develop and the lack of antidote, early decontamination is a vital intervention. The below table gives the doses ingested and the risk factors present that determine whether decontamination |
| ==== Enhanced Elimination ==== | ==== Enhanced Elimination ==== | ||