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| wiki:2.1.7.1.3.1_biguanides [2019/02/19 15:50] – created - external edit 127.0.0.1 | wiki:2.1.7.1.3.1_biguanides [2025/04/13 07:32] (current) – ↷ Links adapted because of a move operation 3.131.83.165 | ||
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| ==== Distribution ==== | ==== Distribution ==== | ||
| - | Metformin is widely distributed into intracellular compartments where it binds to microsomes. The volume of distribution is 1-5 L/kg. There is no plasma protein binding. As a basic drug, its movement into cells (intracellular pH being lower than systemic pH) may be enhanced by [[:wikitox: | + | Metformin is widely distributed into intracellular compartments where it binds to microsomes. The volume of distribution is 1-5 L/kg. There is no plasma protein binding. As a basic drug, its movement into cells (intracellular pH being lower than systemic pH) may be enhanced by [[:concept_serum_alkalinization|systemic alkalinisation]] (Ryder 1984). |
| ==== Metabolism - Elimination ==== | ==== Metabolism - Elimination ==== | ||