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wiki:2.1.11.9.2.4.1_bupropion [2025/04/13 04:21] – ↷ Links adapted because of a move operation 184.72.95.195wiki:2.1.11.9.2.4.1_bupropion [2025/04/13 04:26] (current) – ↷ Links adapted because of a move operation 52.204.174.139
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 ==== Treatment of specific complications ==== ==== Treatment of specific complications ====
  
-**Cardiac effects** \\ Treatment of [[:wikitox:3.4.3.1_cardiac_arrhythmias_and_cardiac_arrest|tachy & bradyarrhythmias]] should be similar to that used in TCA poisoning with [[:concept_systemic_alkalinisation]] as the first line therapy. \\+**Cardiac effects** \\ Treatment of [[:wikitox:3.4.3.1_cardiac_arrhythmias_and_cardiac_arrest|tachy & bradyarrhythmias]] should be similar to that used in TCA poisoning with [[:concept_serum_alkalinization]] as the first line therapy. \\
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 **Seizures** \\ No specific antidote exists for bupropion overdose. Seizures should be managed with airway protection and benzodiazepines. Repeated seizures are common but [[:wikitox:status_epilepticus_and_treatment_of_seizures|status epilepticus]] (although reported) is not.(19) The use of sodium channel blocking drugs (e.g., [[:wikitox:2.1.11.2.1_phenytoin|phenytoin]], carbamazepine) to control seizures might contribute to cardiotoxicity. Therefore, high dose benzodiazepines followed by barbiturates would be the preferred agents for refractory seizures. **Seizures** \\ No specific antidote exists for bupropion overdose. Seizures should be managed with airway protection and benzodiazepines. Repeated seizures are common but [[:wikitox:status_epilepticus_and_treatment_of_seizures|status epilepticus]] (although reported) is not.(19) The use of sodium channel blocking drugs (e.g., [[:wikitox:2.1.11.2.1_phenytoin|phenytoin]], carbamazepine) to control seizures might contribute to cardiotoxicity. Therefore, high dose benzodiazepines followed by barbiturates would be the preferred agents for refractory seizures.