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| Both sides previous revisionPrevious revisionNext revision | Previous revision | ||
| concept_pharmacokinetics_and_toxicokinetics [2025/04/17 22:00] – Refined jkohts | concept_pharmacokinetics_and_toxicokinetics [2025/04/18 01:58] (current) – jkohts | ||
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| - | ===== - Clearance | + | ==== - Clearance ==== |
| **Clearance (Cl)** is the volume of plasma (or blood) from which a drug is completely removed per unit time. It is expressed as volume/time (e.g. mL/min or mL/ | **Clearance (Cl)** is the volume of plasma (or blood) from which a drug is completely removed per unit time. It is expressed as volume/time (e.g. mL/min or mL/ | ||
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| $$Total\ body\ clearance = Cl_{renal} + Cl_{hepatic} + Cl_{lung} + ...$$ | $$Total\ body\ clearance = Cl_{renal} + Cl_{hepatic} + Cl_{lung} + ...$$ | ||
| - | For a specific organ, the clearance is a function of blood flow through that organ, and the proportion of drug that is removed during each pass of the organ (extraction ratio). Thus, ↓ renal perfusion | + | For a specific organ, the clearance is a function of blood flow through that organ, and the proportion of drug that is removed during each pass of the organ (extraction ratio). Thus, ↓ renal blood flow (e.g. shock) will ↓ renal clearance. |
| $$Cl_{renal} = Renal\ blood\ flow\ × Renal\ extraction\ ratio$$ | $$Cl_{renal} = Renal\ blood\ flow\ × Renal\ extraction\ ratio$$ | ||