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Poisoning monographs

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wikitox:problems_for_discussion_2_colchicine

Problems for Discussion - 2 - Colchicine (and colchicine-containing plants)

PROBLEM 1

  1. Why can’t toxicologists agree?
  2. Review the HyperTox monograph and Baud (1995).

PROBLEM 2

  1. Having read Baud’s paper, consider that if you had colchicine antibodies would you use them?
  2. Speculate on what factors make digoxin antibodies available when colchicine antibodies are not.

PROBLEM 3

A 45 year old female presented 1 hour after ingestion of a single tuber of Gloriosa superba. She appeared well.

  1. What is your initial management
  2. She refuses all interventions.
  3. How would you proceed?

PROBLEM 4

A 40 year old male presented 5 hours following ingestion of a long tuber of Gloriosa superba . He appeared unwell with profuse vomiting and blood stained diarrhoea.
His pulse was 110 beats per minute and the blood pressure was 70/60mmHg. The arterial blood gas analysis revealed a pH of 7.1, HCO3 of 12mmol/L, CO2 of 13mmHg and a base excess of -5. Total WBC of 32000/mm3 with 90% neutrophils.

  1. What is your risk assessment
  2. Propose a mechanism for these clinical features
  3. What is your management

72 hours afterwards his urine output was 10ml/hour and the FBC revealed: Hb 5g/dL, WBC 1500/mm3 and platelets 10000/mm3.

  1. What has happened?
  2. What further investigations would you request?
  3. What is your management?
/home/wikitoxo/public_html/data/pages/wikitox/problems_for_discussion_2_colchicine.txt · Last modified: 2018/09/01 09:01 (external edit)