Table of Contents
Myoclonic Jerking or Hyperreflexia
Drugs leading to hyperreflexia or muscle irritability are often those that may cause seizures:
MYOCLONUS and HYPOTENSION
However, if there is compromise of CNS perfusion, then seizures may occur with any of these drugs.
MYOCLONUS, HYPERREFLEXIA and HALLUCINATIONS
Myoclonic jerking (without fitting) is suggestive of the serotonergic syndrome.
Hyperadrenergic states (withdrawal states, sympathomimetic drugs) and the serotonergic syndrome are associated with hyperreflexia. In serotonin toxicity, the hyperreflexia is typically confined to the lower limbs.
MYOCLONUS and ANTICHOLINERGICS
Serotonin reuptake inhibitors can cause prominent myoclonus and tremor that may be confused with seizures. Hyperreflexia from SSRIs is often confined to the lower limbs.