wikitox:methaemoglobin
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wikitox:methaemoglobin [2018/09/01 09:01] – external edit 127.0.0.1 | wikitox:methaemoglobin [2020/05/31 23:50] (current) – andrew | ||
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====== Methaemoglobin ====== | ====== Methaemoglobin ====== | ||
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===== DEFINITION ===== | ===== DEFINITION ===== | ||
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4. Ascorbic acid and reduced glutathione can be used as electron donors to reduce oxidized iron.\\ | 4. Ascorbic acid and reduced glutathione can be used as electron donors to reduce oxidized iron.\\ | ||
a. These methods are much slower and quantitatively less important under normal circumstances. | a. These methods are much slower and quantitatively less important under normal circumstances. | ||
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===== PATHOPHYSIOLOGY ===== | ===== PATHOPHYSIOLOGY ===== | ||
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d. Primarily affect the cardiovascular system and CNS. | d. Primarily affect the cardiovascular system and CNS. | ||
- | | |**Methemoglobin Level** |**Signs and Symptoms***| | + | |**Methemoglobin Level** |**Signs and Symptoms***| | |
|0 to 3%|Normal levels. No symptoms.| | | |0 to 3%|Normal levels. No symptoms.| | | ||
|10 - 20%|Mild symptoms. Cyanosis. Chocolate-brown colored blood.| | | |10 - 20%|Mild symptoms. Cyanosis. Chocolate-brown colored blood.| | | ||
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(a) Tachycardia or tachypnea\\ | (a) Tachycardia or tachypnea\\ | ||
(b) Metabolic acidosis\\ | (b) Metabolic acidosis\\ | ||
- | (c) End-organ dysfunction\\ | + | © End-organ dysfunction\\ |
(i) Altered mental status, seizures\\ | (i) Altered mental status, seizures\\ | ||
(ii) Dysrhythmias, | (ii) Dysrhythmias, | ||
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c. Hyperbaric oxygen.\\ | c. Hyperbaric oxygen.\\ | ||
i. Significantly increases the level of dissolved oxygen in the blood, thereby allowing for adequate oxygen delivery despite the absence of Hb. | i. Significantly increases the level of dissolved oxygen in the blood, thereby allowing for adequate oxygen delivery despite the absence of Hb. | ||
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===== TREATMENT FAILURE ===== | ===== TREATMENT FAILURE ===== | ||
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Rodriguez LF, Smolik LM, Zbehlik AJ: Benzocaine-induced methemoglobinaemia: | Rodriguez LF, Smolik LM, Zbehlik AJ: Benzocaine-induced methemoglobinaemia: | ||
Wright RO, Lewander WJ, Woolf AD. Methemoglobinaemia: | Wright RO, Lewander WJ, Woolf AD. Methemoglobinaemia: | ||
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+ | \\ | ||
wikitox/methaemoglobin.txt · Last modified: 2020/05/31 23:50 by andrew