wikitox:enhanced_elimination
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wikitox:enhanced_elimination [2024/04/29 00:15] – kharris | wikitox:enhanced_elimination [2024/04/29 00:18] (current) – kharris | ||
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Alkalinisation of the urine increases urinary excretion of weak acids (e.g. salicylates, | Alkalinisation of the urine increases urinary excretion of weak acids (e.g. salicylates, | ||
- | Drugs amenable to urinary alkalinisation should be weak acids (pKa > 3), undergo substantial renal elimination and result in clinically significant toxicity. Urinary Alkalinisation is used in the management of salicylate and chlorphenoxy herbicide poisoning. | + | Drugs amenable to urinary alkalinisation should be weak acids (pKa > 3), undergo substantial renal elimination and result in clinically significant toxicity. |
- | To alkalinise the urine, give 1 mmol/kg (up to 100mmol) sodium bicarbonate bolus followed by an infusion of 25 mmol/h. Place an indwelling urinary catheter and monitor urinary pH q2h, aiming for a pH > 7.5. | + | |
+ | Urinary Alkalinisation is used in the management of salicylate and chlorphenoxy herbicide poisoning. | ||
+ | |||
+ | To alkalinise the urine, give **1 mmol/kg (up to 100mmol) sodium bicarbonate bolus followed by an infusion of 25 mmol/h**. Place an indwelling urinary catheter and monitor urinary pH q2h, aiming for a pH > 7.5. | ||
Complications include hypokalaemia, | Complications include hypokalaemia, |
wikitox/enhanced_elimination.txt · Last modified: 2024/04/29 00:18 by kharris