wikitox:chemicals_and_industrial_section_3
Table of Contents
Chemical and Industrial Section 3
AIMS
This module aims to cover the toxicology of the following common or important chemicals:
• Heavy Metals:
• Lead
• Arsenic
• Thallium
• Mercury
• Other heavy metals including bismuth, cadmium and copper
• Products of combustion
• Cyanide
• Carbon Monoxide
• Smoke Inhalation
OBJECTIVES
• At the end of these modules, students should be able to:
- Understand the epidemiology of poisoning by these agents.
- Discuss the target organs and clinical effects of poisoning by these agents.
- Describe the general management of poisonings by these agents.
- Understand the issues with decontamination.
- Understand the advantages and problems with the use of chelating agents.
- In addition to specific objectives in each section
RESOURCES
COMPLETE READING LIST
This list is a cumulative list of all the references in the above modules, the relevant references appear in each section.
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Environ Health Perspect. 2007 Apr;115(4):606-8. (fulltext) - Pi J, Yamauchi H, Sun G, Yoshida T, Aikawa H, Fujimoto W, Iso H, Cui R, Waalkes MP, Kumagai Y.Vascular dysfunction in patients with chronic arsenosis can be reversed by reduction of arsenic exposure.Environ Health Perspect. 2005 Mar;113(3):339-41.(fulltext)
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- Brent J. Toxicologists and the Assessment of Risk: The Problem with Mercury. Clin Toxicol. 2001;39:707-10.
- McFee RB, Caraccio TR. Intravenous mercury injection and ingestion: clinical manifestations and management. Clin Toxicol. 2001;39:733-8.
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- Takeda T, Yukioka T, Shimazaki S.Cupric sulfate intoxication with rhabdomyolysis, treated with chelating agents and blood purification.Intern Med. 2000 Mar;39(3):253-5.(fulltext)
- Erikson KM, Thompson K, Aschner J, Aschner M. Manganese neurotoxicity: a focus on the neonate.Pharmacol Ther. 2007 Feb;113(2):369-77 (fulltext)
- Cherian MA, Richmond I.Fatal methane and cyanide poisoning as a result of handling industrial fish: a case report and review of the literature. J Clin Pathol. 2000 Oct;53(10):794-5 (fulltext)
- Geller RJ, Barthold C, Saiers JA, Hall AH.Pediatric cyanide poisoning: causes, manifestations, management, and unmet needs. Pediatrics. 2006 Nov;118(5):2146-58. (fulltext)
- Baud FJ, Borron SW, Bavoux E, Astier A, Hoffman JR.Relation between plasma lactate and blood cyanide concentrations in acute cyanide poisoning.BMJ. 1996 (fulltext)
- Cummings TF. The treatment of cyanide poisoning. Occup Med (Lond). 2004;54:82-5.
- Sauer SW, Keim ME. Hydroxocobalamin: improved public health readiness for cyanide disasters.Ann Emerg Med. 2001 Jun;37:635-41.
- Mannaioni G, Vannacci A, Marzocca C, et al. Acute cyanide intoxication treated with a combination of hydroxycobalamin, sodium nitrite, and sodium thiosulfate. J Toxicol Clin Toxicol. 2002;40:181-3.
- Baud FJ, Borron SW, Mégarbane B, et al. Value of lactic acidosis in the assessment of the severity of acute cyanide poisoning. Crit Care Med 2002;30:2044-2050.
- Bhowmik D, Mathur R, Bhargava Y, et al. Chronic interstitial nephritis following parenteral copper sulfate poisoning. Ren Failure. 2001;23:731-735.
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- Langford RM, Armstrong RF.Algorithm for managing injury from smoke inhalation.BMJ. 1989 Oct 7;299(6704):902-5. (fulltext)
- Reske A, Bak Z, Samuelsson A, Morales O, et al. Computed tomography - a possible aid in the diagnosis of smoke inhalation injury? Acta Anaesthesiol Scand. 2005;49:257-60.
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wikitox/chemicals_and_industrial_section_3.txt · Last modified: 2018/09/01 09:01 by 127.0.0.1