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wikitox:2.1.6.2.5_vasodilators [2018/09/01 09:00] (current)
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 +Link to [[:​wikitox:​problems_for_discussion_2_vasodilators|Problems for Discussion]]
 +
 +----
 +
 +====== Vasodilators ======
 +
 +This diverse group of drugs can be divided into the following groups:
 +
 +  - Direct acting vasodilators
 +      * Nitrates: Glyceryl trinitrate, Isosorbide Mononitrate,​ Isosorbide Dinitrate
 +      * Nitroprusside
 +      * Hydralazine
 +      * Diazoxide
 +      * Minoxidil
 +  - Alpha Antagonists
 +      * Centrally acting: Clonidine (discussed separately),​ Methyl dopa
 +      * Peripheral Non-selective:​ Phentolamine,​ Phenoxybenzamine
 +      * Peripheral Selective: Prazosin, Terazosin
 +  - Angiotensin acting
 +      * [[:​wikitox:​2.1.6.2.1.1_angiotensin_converting_enzyme_inhibitors|Angiotensin Converting Enzyme Inhibitors]]
 +      * Angiotensin II Receptor Inhibitors: Candesartan,​ Eprosartan, Irbesartan, Losartan, Telmisartan
 +  - [[:​wikitox:​2.1.6.1.1_calcium_channel_blockers|Calcium Channel Blockers]] (discussed separately)
 +
 +===== FURTHER READING =====
 +
 +MacMillan AR, Warshawski FJ, Steinberg RA. Minoxidil overdose. Chest 1993;​103(4):​1290-1 [[http://​www.ncbi.nlm.nih.gov/​pubmed/​8131492|PMID 8131492]]
 +
 +Jahangiri M, Holdright DR. Myocardial infarction secondary to dipyridamole overdose. //Arch Emerg Med// 1992 Mar;​9(1):​62-4 [[http://​www.ncbi.nlm.nih.gov/​pubmed/​1567532|PMID 1567532]]
 +
 +Pigeon G, Genest J. Prolonged hydralazine hydrochloride administration in 132 hypertensive patients–Study of toxicity. //Can Med Assoc J// 1960 Oct 1;83:743-6 [[http://​www.ncbi.nlm.nih.gov/​pubmed/​13735669|PMID 13735669]]
 +
 +Varon J, Duncan SR. Naloxone reversal of hypotension due to captopril overdose. //Ann Emerg Med// 1991;​20(10):​1125-7 [[https://​www.ncbi.nlm.nih.gov/​pubmed/​1928887|PMID 1928887]]
 +
 +Farrell SE, Epstein SK. Overdose of rogaine extra strength for men topical minoxidil preparation. //J Toxicol Clin Toxicol// 1999;​37(6):​781-783 [[https://​www.ncbi.nlm.nih.gov/​pubmed/​10584592|PMID 10584592]]
 +
 +Rygnestad TK, Dale O. Self-poisoning with prazosin. //Acta Med Scand// 1983;​213(2):​157-8 [[https://​www.ncbi.nlm.nih.gov/​pubmed/​6837333|PMID 6837333]]
 +
 +Arora R, Timoney M, Melelli L. Acute Myocardial infarction after the use of sildenafil. //N Eng J Med// 1999;​341(9):​700 [[https://​www.ncbi.nlm.nih.gov/​pubmed/​10475830|PMID 10475830]]
 +
  
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