wikitox:2.1.11.9.1_methaqualone
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+ | ====== Methaqualone ====== | ||
+ | |||
+ | ===== GENERAL ===== | ||
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+ | The miscellaneous anxiolytics, | ||
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+ | |||
+ | ===== TOXIC DOSE ===== | ||
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+ | In any discussion of toxic doses of sedative-hypnotic drugs, there will always be considerable variation due to interindividual differences in tolerance and the contribution or otherwise of active metabolites. | ||
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+ | In a series of chronic drug users, mild toxicity (slurred speech, ataxia, drowsiness and nystagmus) appeared after cumulative doses of 300 – 4900 mg of methaqualone (64). Deep coma (unresponsive to pain) occurred after an estimated ingestion of greater than 4.5 g of methaqualone (65). A 23-year-old man was admitted after ingestion of 4 – 5 g. On admission he was somnolent and poorly responsive to painful stimuli and later became deeply comatose. He recovered completely (66). | ||
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+ | ===== TOXICOKINETICS / TOXICODYNAMICS ===== | ||
+ | |||
+ | In most cases, it is the development of tolerance to sedative-hypnotics that determines the recovery of consciousness after overdose rather than the clearance of the drug. In general, because of tolerance and the active metabolites of these drugs, there is a poor correlation between concentration and effect. | ||
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+ | A 250 mg oral dose produced a mean peak concentration of 2.2 mg/L (range 1.0 – 4.0) (99). Concentrations greater than 8 mg/L have been associated with [[: | ||
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+ | ===== PATHOPHYSIOLOGY ===== | ||
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+ | The mechanism of action of is unclear but there is evidence at least some of its actions are related to effects at the flumazenil-sensitive benzodiazepine recognition site(s) of the GABA(A) receptor-benzodiazepine receptor-chloride ion channel complex (135). Serotonin appears to play a facilitatory role in the anticonvulsant activity of methaqualone (136). The physical dependence picture on methaqualone is closer to that of benzodiazepines than barbiturates and alcohol(137). Methaqualone has been withdrawn from the market in many countries because of problems with abuse (122; | ||
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+ | ===== CLINICAL PRESENTATION ===== | ||
+ | |||
+ | ==== Acute overdose ==== | ||
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+ | In a series of sixty cases of methaqualone ingestion from 1977 through 1980 there was a depressed level of consciousness that, in general, responded to a brief period of observation and supportive care (102). | ||
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+ | More severe methaqualone overdose can produce early CNS excitation (66) (occasionally), | ||
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+ | There is one case report of hemorrhagic complications possibly due to methaqualone-induced thrombocytopenia (218) and/or platelet dysfunction (219). | ||
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+ | ==== Acute withdrawal ==== | ||
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+ | Withdrawal from central nervous system depressants is dealt with in more detail in the [[: | ||
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+ | |||
+ | ==== Adverse reactions ==== | ||
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+ | Unwanted sedation and other symptoms of CNS depression are recognised adverse effects of methaqualone. Peripheral neuropathies are a significant problem (232). Fixed drug eruptions (233) and erythema multiforme (234) are reported. Platelet aggregation can be impaired with consequent bleeding disorder (219) and the possiblility of agranulocytosis due to methaqualone has been suggested (235). Drug-induced gout has been reported with methaqualone (236). | ||
+ | |||
+ | ===== DIAGNOSTIC TESTS ===== | ||
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+ | Routine quantitative drug estimation is not readily available for any of these agents and not indicated for routine management. Hepatic and renal function tests are indicated. Measurement of creatine kinase in cases of coma will help in the assessment of [[: | ||
+ | |||
+ | |||
+ | ==== Postmortem considerations ==== | ||
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+ | For many drugs, there is a postmortem diffusion of drugs along a concentration gradient, from sites of high concentration in solid organs, into the blood with resultant artifactual elevation of drug concentrations in blood (postmortem redistribution). Highest drug concentrations are found in central vessels such as pulmonary artery and vein, and lowest concentrations are found in peripheral vessels such as subclavian and femoral veins. This creates major difficulties in interpretation and undermines the reference value of data bases where the site of origin of postmortem blood samples is unknown (240). It is widely agreed, however, that the femoral vein site represents the optimum sampling site and this site is now standardised amongst forensic pathologists. | ||
+ | |||
+ | ===== TREATMENT ===== | ||
+ | |||
+ | ==== Overview ==== | ||
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+ | Oral [[: | ||
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+ | Patients with a significant sedative drug overdose should be advised not to drive until potential interference with psychomotor performance has resolved (260). For overdose of most of these agents this will be at least 48 hours after discharge. | ||
+ | |||
+ | |||
+ | ==== Elimination enhancement ==== | ||
+ | |||
+ | Principles of [[: | ||
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+ | Although there are numerous case reports of the use of a variety of techniques in methaqualone poisoning (101; | ||
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+ | |||
+ | ==== Monitoring ==== | ||
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+ | Routine observation of vital signs, especially GCS airway patency and blood pressure, is indicated. For the older agents, continuous arterial blood pressure monitoring should be considered. Measurement of partial pressure of carbon dioxide via expired air or arterial blood gases is the best way to assess respiratory compromise from sedation. | ||
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+ | ===== REFERENCES ===== | ||
+ | |||
+ | (1) Smith AJ, Whyte IM. New drugs for old: an issue for debate? Med J Aust 1988; 149(11–12): | ||
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+ | (64) Faulkner TP, Hayden JH, Mehta CM, Olson DA, Comstock EG. Dose-response studies on tolerance to multiple doses of secobarbital and methaqualone in a polydrug abuse population. Clin Toxicol 1979; 15(1): | ||
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+ | (65) Baggish D, Gray S, Jatlow P, Bia MJ. Treatment of methaqualone overdose with resin hemoperfusion. Yale J Biol Med 1981; 54(2): | ||
+ | |||
+ | (66) Kurz RW, Hainz R, Gremmel F, Grisold W, Hruby K, Dellert P et al. [Dangerous intoxication from extreme serum concentrations of methaqualone metabolites. Detection and quantification of biosynthesis with gas chromatography-mass spectrometry]. Anaesthesist 1995; 44(12): | ||
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+ | (99) Brown SS, Goenechea S. Methaqualone: | ||
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+ | (100) Bailey DN, Jatlow PI. Methaqualone overdose: analytical methodology, | ||
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+ | (101) Proudfoot AT, Noble J, Nimmo J, Brown SS, Cameron JC. Peritoneal dialysis and haemodialysis in methaqualone (Mandrax) poisoning. Scott Med J 1967; 13(7): | ||
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+ | (102) Bailey DN. Methaqualone ingestion: evaluation of present status. J Anal Toxicol 1981; 5(6): | ||
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+ | (122) Sweetman S. Martindale: The Complete Drug Reference. London: Pharmaceutical Press. Electronic ed. expires 03/2003 Greenwood Village, Colorado: MICROMEDEX, 2003 | ||
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+ | (135) Hicks TP, Kaneko T, Oka JI. Receptive-field size of S1 cortical neurones is altered by methaqualone via a GABA mechanism. Can J Neurol Sci 1990; 17(1): | ||
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+ | (136) Leadbetter MI, Parmar SS. Serotonin as a facilitatory neurotransmitter in the anticonvulsant activity of methaqualone. Physiol Behav 1989; 46(1): | ||
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+ | (137) Suzuki T, Koike Y, Chida Y, Misawa M. Cross-physical dependence of several drugs in methaqualone-dependent rats. Jpn J Pharmacol 1988; 46(4): | ||
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+ | (138) Inaba DS, Ray GR, Newmeyer JA, Whitehead C. Methaqualone abuse. " | ||
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+ | (139) Pascarelli EF. Methaqualone abuse, the quiet epidemic. JAMA 1973; 224(11): | ||
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+ | (206) Gaultier M, Pebay-Peyroula FC, Griffoul E, Mellerio F. [Acute poisoning due to Mandrax]. Eur J Toxicol 1972; 5(2): | ||
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+ | (207) Jouglard J, Airaudo CB, Di Costanzo J, Grigorian G, Robaglia JL, Hebrard MJ et al. [Acute poisoning by Mandrax. Evaluation of known cases at the Marseilles Poison Control Center (88 cases in 27 months)]. Mars Med 1972; 109(9): | ||
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+ | (208) Ibe K. [Acute methaqualone poisoning. II. Clinical picture, pathophysiology and therapy]. Arch Toxikol 1966; 21(5): | ||
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+ | (209) Zabransky S. [Eatan poisoning in childhood. Dyskinetic, deliriant syndrome with unilateral symptoms and cerebellar deficit]. Anasthesiol Intensivmed Prax 1975; 10(1): | ||
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+ | (210) Roman D. Schizophrenia-like psychosis following ' | ||
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+ | (211) Mack RB. Methaqualone intoxication. N C Med J 1981; 42(11):796 | ||
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+ | (212) Abboud RT, Freedman MT, Rogers RM, Daniele RP. Methaqualone poisoning with muscular hyperactivity necessitating the use of curare. Chest 1974; 65(2): | ||
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+ | (213) Pan HY, Huang CY. Alternating skew deviation associated with Mandrax overdosage. Aust N Z J Med 1984; 14(3): | ||
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+ | (214) Thamdrup B, Jensen S, Ostergaard OV. [Methaqualone poisoning treated with hemoperfusion]. Ugeskr Laeger 1983; 145(18): | ||
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+ | (215) Johnstone RE, Manitsas GT, Smith EJ. Apnea following methaqualone ingestion. Report of a case. Ohio State Med J 1971; 67(11): | ||
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+ | (216) Holmberg G, Wiklund PE. [Treatment of acute poisoning. 8. Intoxications with preparations containing methaqualone]. Lakartidningen 1971; 68:Suppl. I:109+ | ||
+ | |||
+ | (217) Oh TE, Gordon TP, Burden PW. Unilateral pulmonary oedema and " | ||
+ | |||
+ | (218) Trese M. Retinal hemorrhage caused by overdose of methaqualone (Quaalude). Am J Ophthalmol 1981; 91(2): | ||
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+ | (219) Mills DG. Effects of methaqualone on blood platelet function. Clin Pharmacol Ther 1978; 23(6): | ||
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+ | (227) Benzodiazepines. In: Rossi S, Vitry A, Hurley E, Abbott F, Goldsworthy S, editors. Australian Medicines Handbook. Adelaide: Australian Medicines Handbook Pty Ltd, 2002 | ||
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+ | (228) Coupey SM. Barbiturates. [Review] [13 refs]. Pediatr Rev 1997; 18(8): | ||
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+ | (229) van Sweden B, Mellerio F. Toxic ictal delirium. Biol Psychiatry 1989; 25(4): | ||
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+ | (232) Marks P, Sloggem J. Peripheral neuropathy caused by methaqualone. Am J Med Sci 1976; 272(3): | ||
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+ | (233) Slazinski L, Knox DW. Fixed drug eruption due to methaqualone. Arch Dermatol 1984; 120(8): | ||
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+ | (234) Parish LC, Cander L, Witkowski JA. Erythema multiforme due to methaqualone. Acta Derm Venereol 1981; 61(1): | ||
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+ | (235) Azizi F. Letter: Agranulocytosis from methaqualone? | ||
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+ | (236) Chan OL. Letter: Drug-precipitated acute attacks of gout. BMJ 1975; 2(5970):561 | ||
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+ | (240) Pounder DJ, Jones GR. Post-mortem drug redistribution–a toxicological nightmare. Forensic Sci Int 1990; 45(3): | ||
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+ | (281) Koffler A, Bernstein M, LaSette A, Massry SG. Fixed-bed charcoal hemoperfusion. Treatment of drug overdose. Arch Intern Med 1978; 138(11): | ||
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+ | (286) De Broe ME, Verpooten GA, Christiaens MA, Rutsaert RJ, Holvoet J, Nagler J et al. Clinical experience with prolonged combined hemoperfusion-hemodialysis treatment of severe poisoning. Artif Organs 1981; 5(1): | ||
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+ | (288) de Torrente A, Rumack BH, Blair DT, Anderson RJ. Fixed-bed uncoated charcoal hemoperfusion in the treatment of intoxications: | ||
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+ | (289) Okonek S. [Hemoperfusion with coated activated charcoal for treating acute poisoning by remedies, plant protectants, | ||
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+ | (290) Matthew H, Proudfoot AT, Brown SS, Smith AC. Mandrax poisoning: conservative management of 116 patients. BMJ 1968; 2(597): | ||
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wikitox/2.1.11.9.1_methaqualone.txt · Last modified: 2018/09/01 09:00 by 127.0.0.1