This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong. ====== Problems for Discussion - 1 - Salicylates ====== ===== Objectives ===== * Understand the mechanism and treatment of salicylate poisoning * Understand effects of urinary alkalinisation ==== Problem 1 ==== An 18-year-old girl, 60 kg, 5 hours previously ingested 80 x 300 mg soluble aspirin washed down with a large amount of cheap wine. She is nauseated, vomiting complains of buzzing in her ears. Drowsy but responds purposefully. Pulse 120, BP 105/60, RR 18. You order some investigations * Breath Alcohol 0.16 * Glucose 6.4 mmol/L * ABGs * pH 7.32 * pCOB2B 28 * pOB2B 112 * HCOB3B 13 * Electrolytes Normal * Urine pH 6 - Would you decontaminate her? - Discuss her management, detailing your interventions and how you would monitor therapy. - What is the implication of co-ingestion of alcohol (or other sedatives) in this situation? CKG Edit