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wikitox:cholinergictoxicity [2025/02/16 16:49] – kharriswikitox:cholinergictoxicity [2025/02/17 00:33] (current) – kharris
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- <font 36px/inherit;;#c12b04;;inherit>Cholinergic Toxicity</font> +====== Cholinergic Toxicity ======
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 ===== Introduction ===== ===== Introduction =====
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 ===== Mechanism of Toxic Effects ===== ===== Mechanism of Toxic Effects =====
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 Cholinergic toxicity occurs when there is excess acetylcholine activity in the body. This can occur from decreased breakdown of acetylcholine due to the presence of acetylcholinesterase inhibitors or direct stimulation by acetylcholine receptor agonists. Cholinergic toxicity occurs when there is excess acetylcholine activity in the body. This can occur from decreased breakdown of acetylcholine due to the presence of acetylcholinesterase inhibitors or direct stimulation by acetylcholine receptor agonists.
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 ===== Cholinergic agents ===== ===== Cholinergic agents =====
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 **Acetylcholinesterase Inhibitors (effect both muscarinic and nicotinic system) include:** **Acetylcholinesterase Inhibitors (effect both muscarinic and nicotinic system) include:**
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 ===== Clinical Presentation ===== ===== Clinical Presentation =====
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 **CNS effects:**  Coma, seizures, agitation/delirium \\  \\ **Autonomic effects:**  salivation, lacrimation, sweating, flushing, miosis \\  \\ **Neuromuscular effects:**  Fasciculations, weakness/paralysis \\  \\ **Cardiovascular effects:**  Bradycardia or tachycardia (common early), hyper/hypotension \\  \\ **Respiratory effects:**  Bronchoconstriction, bronchorrhea \\  \\ **Gastrointestinal effects:**  vomiting, diarrhoea **CNS effects:**  Coma, seizures, agitation/delirium \\  \\ **Autonomic effects:**  salivation, lacrimation, sweating, flushing, miosis \\  \\ **Neuromuscular effects:**  Fasciculations, weakness/paralysis \\  \\ **Cardiovascular effects:**  Bradycardia or tachycardia (common early), hyper/hypotension \\  \\ **Respiratory effects:**  Bronchoconstriction, bronchorrhea \\  \\ **Gastrointestinal effects:**  vomiting, diarrhoea
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 ===== Management ===== ===== Management =====
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 The main priorities in management are treatment of muscarinic effects and airway management. For advice regarding specific agents, see the relevant monograph. The main priorities in management are treatment of muscarinic effects and airway management. For advice regarding specific agents, see the relevant monograph.