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| wikitox:cholinergictoxicity [2025/02/16 16:47] – kharris | wikitox:cholinergictoxicity [2025/02/17 00:33] (current) – kharris | ||
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| ===== Introduction ===== | ===== Introduction ===== | ||
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| Cholinergic toxicity occurs when there is excess acetylcholine activity in the body. This can occur from decreased breakdown of acetylcholine due to the presence of acetylcholinesterase inhibitors or direct stimulation by acetylcholine receptor agonists. | Cholinergic toxicity occurs when there is excess acetylcholine activity in the body. This can occur from decreased breakdown of acetylcholine due to the presence of acetylcholinesterase inhibitors or direct stimulation by acetylcholine receptor agonists. | ||
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| ===== Cholinergic agents ===== | ===== Cholinergic agents ===== | ||
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| - | It is common to require an ongoing infusion of 10-20% of the total dose of atropine required to achieve atropinisation of the patient per hour. \\ \\ | + | It is common to require an ongoing infusion of 10-20% of the total dose of atropine required to achieve atropinisation of the patient per hour. \\ \\ |
| During titration observe for signs of over atropinisation (confusion, pyrexia, loss of bowel sounds). \\ \\ | During titration observe for signs of over atropinisation (confusion, pyrexia, loss of bowel sounds). \\ \\ | ||
| Intravenous benzodiazepines should be used to manage agitation and seizures. \\ \\ | Intravenous benzodiazepines should be used to manage agitation and seizures. \\ \\ | ||