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concept_serum_alkalinization [2025/07/18 00:09] – [2. Hyperventilation] kharrisconcept_serum_alkalinization [2025/08/19 06:38] (current) – jkohts
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-===== 1. Hyperventilation =====+===== - Hyperventilation =====
  
 This is generally only feasible in patients who are mechanically ventilated but can be used to assist systemic alkalinization [(9737495>[[https://pubmed.ncbi.nlm.nih.gov/9737495/|PMID: 9737495]]. McCabe JL, Cobaugh DJ, Menegazzi JJ, Fata J. Experimental tricyclic antidepressant toxicity: a randomized, controlled comparison of hypertonic saline solution, sodium bicarbonate, and hyperventilation. Ann Emerg Med. 1998;32(3 Pt 1):329-333. doi:10.1016/s0196-0644(98)70009-5 {{:mccabe_1998_tca_hts_bicarb_hyperventilation.pdf|PDF}} )]. When combined with sodium bicarbonate administration, there is a risk of inducing profound alkalemia. Thus, serum pH should be closely monitored to avoid complications associated with excessive alkalinization. This is generally only feasible in patients who are mechanically ventilated but can be used to assist systemic alkalinization [(9737495>[[https://pubmed.ncbi.nlm.nih.gov/9737495/|PMID: 9737495]]. McCabe JL, Cobaugh DJ, Menegazzi JJ, Fata J. Experimental tricyclic antidepressant toxicity: a randomized, controlled comparison of hypertonic saline solution, sodium bicarbonate, and hyperventilation. Ann Emerg Med. 1998;32(3 Pt 1):329-333. doi:10.1016/s0196-0644(98)70009-5 {{:mccabe_1998_tca_hts_bicarb_hyperventilation.pdf|PDF}} )]. When combined with sodium bicarbonate administration, there is a risk of inducing profound alkalemia. Thus, serum pH should be closely monitored to avoid complications associated with excessive alkalinization.
  
-===== Educational Resources =====+===== - Educational Resources =====
  
 [[https://player.vimeo.com/video/908030027?h=33d58b4b70|Video: Why all the bicarb? Pitfalls of overtreatment - A/Prof Katherine Isoardi - TAPNA ASM 2023]] [[https://player.vimeo.com/video/908030027?h=33d58b4b70|Video: Why all the bicarb? Pitfalls of overtreatment - A/Prof Katherine Isoardi - TAPNA ASM 2023]]