Differences

This shows you the differences between two versions of the page.

Link to this comparison view

Both sides previous revisionPrevious revision
Next revision
Previous revision
concept_serum_alkalinization [2025/05/12 06:56] – [1. Sodium Bicarbonate Administration] jkohtsconcept_serum_alkalinization [2025/08/19 06:38] (current) jkohts
Line 17: Line 17:
  
 ===== - Hyperventilation ===== ===== - Hyperventilation =====
-This is generally only feasible in patients who are mechanically ventilated but can be used to assist systemic alkalinization [(9737495>[[https://pubmed.ncbi.nlm.nih.gov/9737495/|PMID: 9737495]]. McCabe JL, Cobaugh DJ, Menegazzi JJ, Fata J. Experimental tricyclic antidepressant toxicity: a randomized, controlled comparison of hypertonic saline solution, sodium bicarbonate, and hyperventilation. Ann Emerg Med. 1998;32(3 Pt 1):329-333. doi:10.1016/s0196-0644(98)70009-5 {{ :mccabe_1998_tca_hts_bicarb_hyperventilation.pdf |PDF}})]. When combined with sodium bicarbonate administration, there is a risk of inducing profound alkalemia. Thus, serum pH should be closely monitored to avoid complications associated with excessive alkalinization. 
  
 +This is generally only feasible in patients who are mechanically ventilated but can be used to assist systemic alkalinization [(9737495>[[https://pubmed.ncbi.nlm.nih.gov/9737495/|PMID: 9737495]]. McCabe JL, Cobaugh DJ, Menegazzi JJ, Fata J. Experimental tricyclic antidepressant toxicity: a randomized, controlled comparison of hypertonic saline solution, sodium bicarbonate, and hyperventilation. Ann Emerg Med. 1998;32(3 Pt 1):329-333. doi:10.1016/s0196-0644(98)70009-5 {{:mccabe_1998_tca_hts_bicarb_hyperventilation.pdf|PDF}} )]. When combined with sodium bicarbonate administration, there is a risk of inducing profound alkalemia. Thus, serum pH should be closely monitored to avoid complications associated with excessive alkalinization.
 +
 +===== - Educational Resources =====
 +
 +[[https://player.vimeo.com/video/908030027?h=33d58b4b70|Video: Why all the bicarb? Pitfalls of overtreatment - A/Prof Katherine Isoardi - TAPNA ASM 2023]]