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| biguanide_toxicity [2025/03/28 17:13] – jkohts | biguanide_toxicity [2025/04/13 12:54] (current) – ↷ Links adapted because of a move operation 18.220.216.164 | ||
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| ===== DRUGS INCLUDED IN THIS CATEGORY ===== | ===== DRUGS INCLUDED IN THIS CATEGORY ===== | ||
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| ==== Distribution ==== | ==== Distribution ==== | ||
| - | Metformin is widely distributed into intracellular compartments where it binds to microsomes. The volume of distribution is 1-5 L/kg. There is no plasma protein binding. As a basic drug, its movement into cells (intracellular pH being lower than systemic pH) may be enhanced by [[: | + | Metformin is widely distributed into intracellular compartments where it binds to microsomes. The volume of distribution is 1-5 L/kg. There is no plasma protein binding. As a basic drug, its movement into cells (intracellular pH being lower than systemic pH) may be enhanced by [[concept_serum_alkalinization|systemic alkalinisation]] (Ryder 1984). |
| ==== Metabolism - Elimination ==== | ==== Metabolism - Elimination ==== | ||