Differences
This shows you the differences between two versions of the page.
| Both sides previous revisionPrevious revisionNext revision | Previous revision | ||
| biguanide_toxicity [2025/03/28 17:11] – ↷ Page moved and renamed from wikitox:2.1.7.1.3.1_biguanides to biguanide_toxicity jkohts | biguanide_toxicity [2025/04/13 12:54] (current) – ↷ Links adapted because of a move operation 18.220.216.164 | ||
|---|---|---|---|
| Line 3: | Line 3: | ||
| ---- | ---- | ||
| - | ====== | + | ====== |
| ===== DRUGS INCLUDED IN THIS CATEGORY ===== | ===== DRUGS INCLUDED IN THIS CATEGORY ===== | ||
| Line 29: | Line 29: | ||
| ==== Distribution ==== | ==== Distribution ==== | ||
| - | Metformin is widely distributed into intracellular compartments where it binds to microsomes. The volume of distribution is 1-5 L/kg. There is no plasma protein binding. As a basic drug, its movement into cells (intracellular pH being lower than systemic pH) may be enhanced by [[: | + | Metformin is widely distributed into intracellular compartments where it binds to microsomes. The volume of distribution is 1-5 L/kg. There is no plasma protein binding. As a basic drug, its movement into cells (intracellular pH being lower than systemic pH) may be enhanced by [[concept_serum_alkalinization|systemic alkalinisation]] (Ryder 1984). |
| ==== Metabolism - Elimination ==== | ==== Metabolism - Elimination ==== | ||
| Line 35: | Line 35: | ||
| Buformin and metformin are renally cleared by glomerular filtration and the various cation transport systems (OCT1–3, MATE1 and MATE2K) affect its pharmacokinetics and pharmacodynamics thus there are interactions with cimetidine and other basic cations and genetic variability. Phenformin is both metabolised by CYP2D6 and renally cleared. The half-life of all of these drugs is greatly prolonged with renal impairment and the half-life of phenformin is also prolonged in those without CYP2D6 (8 to 9% of Caucasians) and in severe liver disease. | Buformin and metformin are renally cleared by glomerular filtration and the various cation transport systems (OCT1–3, MATE1 and MATE2K) affect its pharmacokinetics and pharmacodynamics thus there are interactions with cimetidine and other basic cations and genetic variability. Phenformin is both metabolised by CYP2D6 and renally cleared. The half-life of all of these drugs is greatly prolonged with renal impairment and the half-life of phenformin is also prolonged in those without CYP2D6 (8 to 9% of Caucasians) and in severe liver disease. | ||
| - | {{: | + | {{: |
| - | {{ : | + | |
| ===== CLINICAL EFFECTS ===== | ===== CLINICAL EFFECTS ===== | ||